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Carbomer for Ophthalmic Applications

NM-Carbomer as Excipinets for Ophthalmic Applications

Delivery of therapeutics to the human eye is one of the most interesting, but challenging, endeavors a formulator can take on. Anhui Newman is well-equipped to meet your needs for ophthalmic formulation development, in both the anterior and posterior segments of the eye.

NM-Carbomer products are versatile and efficient in complex topical mucosal formulations. These monograph-compliant, mucoadhesive excipients are compatible with most active pharmaceutical ingredients (APIs) and provide essential properties for effective ocular formulation development, including:


  • Bioadhesion / Mucoadhesion – maximize drug absorption by prolonging contact time with the eye, which can increase bioavailability, reduce dosing frequency, and subsequently improve patient compliance
  • Versatility – compatible with a wide variety of acidic, basic, and neutral APIs across a broad pH range while providing customizable rheology and viscosity for your product
  • Emulsification – ability to suspend oils in solution and suitable salt tolerance, which are important qualities for many topical products such as eye drops
  • Non-irritating and non-toxic – enhances patient comfort and safety


All polymers listed in the chart below are suitable for use in ocular applications and are present in ophthalmic commercialized products. Ocular applications can include solutions, suspensions, emulsions, and gels.

NM-Carbomers asOphthalmic Care Excipients

Product

Trade Name

Polymerization    

Solvents1

China

(ChP)

Europe

(Ph. Eur.)

United States

(USP/NF)

    NM-Carbomer  

981G

Cosolvent

Carbomer Homopolymer

Type A

  Carbomers        

 Carbomer Homopolymer             

Type A

NM-Carbomer

980G

Cosolvent

Carbomer Homopolymer

Type C

Carbomers

Carbomer Homopolymer

Type C

NM-Carbomer

971P

Ethyl Acetate

Carbomer Homopolymer

Type A

Carbomers

Carbomer Homopolymer

Type A

NM-Carbomer

974P

Ethyl Acetate

Carbomer Homopolymer

Type B

Carbomers

Carbomer Homopolymer

Type B

NM-Carbomer

934P

Cosolvent

Carbomer Homopolymer

Type B

Carbomers

Carbomer Homopolymer

Type B

NM-Carbomer

2020G

Cosolvent

  Carbomer Interpolymer     

Type B

_

Carbomer Interpolymer

Type B

NM-Carbomer

1382G

CoSolvent

Carbomer Copolymer

Type B

_

Carbomer Copolymer

Type B

NM-Carbomer

TR-1 P

Cosolvent

Carbomer Copolymer

Type B

_

Carbomer Copolymer

Type B

NM-Carbomer

TR-2 P

Cosolvent

Carbomer Copolymer

Type A

_

Carbomer Copolymer

Type A

1 Cosolvent = mixture of Ethyl acetate (class III solvent) and Cyclohexane (class II solvent).

    A total of

    1

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